RAPID | for identifying and exploiting enzyme catalysis.

Isoquinoline

Total number of reactions: 8

Product	Enzyme	Expression System	Reference
2-hydroxyisoquinoline	Toluene 2,3-dioxygenase	Pseudomonas putida UV4	+
Barr, S. A., Boyd, D. R., Sharma, N. D., Hamilton, L., Austin, R., McMordie, S., & Dalton, H. (1994). Bacterial aromatic hydroxylation: cis-dihydrodiol metabolites and their possible role in the “NIH shift.” J. Chem. Soc., Chem. Commun., (17), 1921–1922. doi: 10.1039/C39940001921
isoquinolin-4-ol	Toluene 2,3-dioxygenase	Pseudomonas putida UV4	+
Barr, S. A., Boyd, D. R., Sharma, N. D., Hamilton, L., Austin, R., McMordie, S., & Dalton, H. (1994). Bacterial aromatic hydroxylation: cis-dihydrodiol metabolites and their possible role in the “NIH shift.” J. Chem. Soc., Chem. Commun., (17), 1921–1922. doi: 10.1039/C39940001921
Isoquinolin-5-ol	Toluene 2,3-dioxygenase	Pseudomonas putida UV4	+
Barr, S. A., Boyd, D. R., Sharma, N. D., Hamilton, L., Austin, R., McMordie, S., & Dalton, H. (1994). Bacterial aromatic hydroxylation: cis-dihydrodiol metabolites and their possible role in the “NIH shift.” J. Chem. Soc., Chem. Commun., (17), 1921–1922. doi: 10.1039/C39940001921
8-hydroxyisoquinoline	Toluene 2,3-dioxygenase	Pseudomonas putida UV4	+
Barr, S. A., Boyd, D. R., Sharma, N. D., Hamilton, L., Austin, R., McMordie, S., & Dalton, H. (1994). Bacterial aromatic hydroxylation: cis-dihydrodiol metabolites and their possible role in the “NIH shift.” J. Chem. Soc., Chem. Commun., (17), 1921–1922. doi: 10.1039/C39940001921
Isoquinolin-5-ol	Naphthalene 1,2-dioxygenase	Escherichia coli JM109 pDTG141	+
Chopard, C., Bertho, G., & Prangé, T. (2012). Naphthalene-dioxygenase catalysed cis-dihydroxylation of bicyclic azaarenes. RSC Adv., 2(2), 605–615. doi: 10.1039/c1ra00706h
cis-7,8-dihydroisoquinoline-7,8-diol	Naphthalene 1,2-dioxygenase	Escherichia coli JM109 pDTG141	+
Chopard, C., Bertho, G., & Prangé, T. (2012). Naphthalene-dioxygenase catalysed cis-dihydroxylation of bicyclic azaarenes. RSC Adv., 2(2), 605–615. doi: 10.1039/c1ra00706h
cis-5,6-dihydroisoquinoline-5,6-diol	Naphthalene 1,2-dioxygenase	Escherichia coli JM109 pDTG141	+
Chopard, C., Bertho, G., & Prangé, T. (2012). Naphthalene-dioxygenase catalysed cis-dihydroxylation of bicyclic azaarenes. RSC Adv., 2(2), 605–615. doi: 10.1039/c1ra00706h
isoquinolin-4-ol	Naphthalene 1,2-dioxygenase	Escherichia coli JM109 pDTG141	+
Chopard, C., Bertho, G., & Prangé, T. (2012). Naphthalene-dioxygenase catalysed cis-dihydroxylation of bicyclic azaarenes. RSC Adv., 2(2), 605–615. doi: 10.1039/c1ra00706h